This study represents the first use of hiPSC technology to model the effects of spaceflight on humancardiomyocyte structure and function.
2
The lack of appropriate humancardiomyocyte-based experimental platform has largely hindered the study of cardiac diseases and the development of therapeutic strategies.
3
This system should permit identification of regulatory pathways for humancardiomyocyte proliferation and may facilitate expansion of cardiomyocytes from human ES cells for therapeutic purposes.
4
Methods and results: Herein, we demonstrate that mouse and humancardiomyocytes express the TWEAK receptor Fn14.
5
The effect of purified KCNQ1 antibodies on humancardiomyocytes derived from induced pluripotent stem cells was then studied.
Uso de human cardiomyocytes em inglês
1
Methods and results: Herein, we demonstrate that mouse and humancardiomyocytes express the TWEAK receptor Fn14.
2
The effect of purified KCNQ1 antibodies on humancardiomyocytes derived from induced pluripotent stem cells was then studied.
3
Currently, the immaturity of humancardiomyocytes derived from stem cells limits their utility for regenerative medicine and biological research.
4
Moreover, whether these Ca(2+) release channels are present and play a critical role in humancardiomyocytes remains to be defined.
5
We validated the technique on humancardiomyocytes either freshly isolated or selectively excised from fixed sections of human myocardium by Laser Capture Microdissection.
6
We validate optical actuation by virally introducing optogenetic drivers in rat and humancardiomyocytes or through the modular use of dedicated light-sensitive somatic 'spark' cells.